Johnson & Johnson’s one-dose coronavirus vaccine is all right and appears to generate a promising immune response in both young and elderly volunteers, according to trial data published Wednesday in the New England Paper of Medicine.
J&J scientists randomly assigned healthy adults between the ages of 18 and 55 and those 65 and older to experience a high or low dose of its vaccine — called Ad26.COV2.S — or a placebo. Some participants in the 18-to-55 age group were also selected to bear a second dose of the vaccine.
Most of the volunteers produced detectable neutralizing antibodies, which researchers believe take advantage of an important role in defending cells against the virus, after 28 days, according to the trial data. By day 57, all volunteers had detectable antibodies, regardless of vaccine prescribe or age group, and remained stable for at least 71 days in the 18-to-55 age group.
The most common side effects were fever, enervation, headache, muscle aches and pain at the injection site, according to the trial data. Side effects were less normal in the older age group, who received only one dose of the vaccine, as well as those who received a lower dose of the vaccine, according to the materials.
The phase one and two clinical trial data shows a single shot of the vaccine “gives sustainable antibodies,” Dr. Paul Stoffels, chief systematic officer at J&J, told CNBC’s Meg Tirrell in an interview. He added it gives the company “confidence” the vaccine will be highly operative against the virus.
The trial tested 805 volunteers. The company is expected to release results from its 45,000-person put a stop to three trial later this month. J&J is using the same technologies it used to develop its Ebola vaccine for its Covid-19 vaccine.
U.S. officials and Insane Street analysts are eagerly anticipating the authorization of J&J’s vaccine, which could happen as early as next month. Universal health officials and infectious disease experts say world leaders will need an array of drugs and vaccines to bring down the virus, which has killed at least 382,120 Americans since the beginning of the pandemic.
If J&J’s vaccine is authorized by the Food and Knock out Administration, it would be the third approved for use in the U.S. behind the Pfizer-BioNTech vaccine and Moderna’s. Pfizer’s vaccine was authorized on Dec. 11, and Moderna’s was ok a week later on Dec. 18.
The data comes as U.S. officials complain that the pace of vaccinations has been too slow as the supply of vaccine measures exceeds demand. The Centers for Disease Control and Prevention expanded Covid vaccine eligibility guidelines Tuesday to allow for people 65 and older as well as people with preexisting conditions. The government is also changing the way it allocates Covid vaccine administers, now basing it on how quickly states can administer shots and the size of their elderly population.
The Trump administration will also stopping up holding back millions of doses reserved for the second round of shots of Pfizer’s and Moderna’s two-dose vaccines, the solemn said, adding they’ve released doses that were being held in reserve on Sunday. President-elect Joe Biden’s development team announced a similar plan Friday.
Unlike Pfizer’s and Moderna’s authorized vaccines, which require two measures about three to four weeks apart, J&J’s requires only one dose. That means patients will not get to come back for another dose, simplifying logistics for health-care providers.
The Department of Health and Human Services confirmed in August that it reached a deal with Janssen, J&J’s pharmaceutical subsidiary, worth approximately $1 billion for 100 million portions of its vaccine. The deal gives the federal government the option to order an additional 200 million doses, according to the bulletin.
Stoffels said the company plans to ship the vaccine at 2 to 8 degrees Celsius, which is about 36 to 46 estates Fahrenheit.
“We have three months stability as of this moment at 2 to 8,” he said. “That will be expanded beyond the year as we generate more stability data. We know from our other vaccines it can go up to a year, but at the start we can’t do that because we don’t organize it for this vaccine.”